Sanjay Srivastava, Ph.D.
580 S. Preston St.
Delia Baxter Bldg., Rm. 421B
Louisville, KY 40202
Phone: (502) 852-5834
Fax: (502) 852-3663
E-mail: mailto:s0sriv01@gwise.louisville.edu
Research Interests
Dr. Srivastava has a Ph.D. from Lucknow University, Lucknow, India. His research interests include aldehyde metabolism and detoxification. He is working to delineate the mechanisms by which aldehydes derived from the peroxidation of lipoproteins and membrane lipids affect cell metabolism, gene expression and growth. His current research is to identify the major metabolic pathways that detoxify lipid peroxidation products in cardiovascular tissues. To this aim, he is characterizing the nature of the covalent adducts formed between these aldehydes and cellular proteins and DNA; and the contribution of these modifications to the cytotoxicity and genotoxicity of lipid peroxidation products.
Publications
- Srivastava, S., Chandrasekar, B., Bhatnagar, A., and Prabhu, S. Lipid peroxidation derived aldehydes and oxidative stress in the failing heart: role of aldose reductase. Am. J. Physiol. 283, H2612-H2619, 2002.
- Srivastava, S., Conklin, D.J., Liu, S.-Q., Prakash, N., Boor, P.J., Srivastava, S.K., and Bhatnagar, A. Identification of biochemical pathways for the metabolism of oxidized low-density lipoprotein-derived aldehyde- 4- hydroxy trans-2-nonenal in vascular smooth muscle cells. Atherosclerosis 158, 339-350, 2001.
- Srivastava, S., Watowich, S., Petrash, J.M., Srivastava, S.K., and Bhatnagar, A. Structural and kinetic properties of aldehyde reduction by aldose reductase. Biochemistry 38, 42-54, 1999.
- Srivastava, S., Harter, T.M., Chandra, A., Bhatnagar, A., Srivastava, S.K., and Petrash, J.M. Kinetic studies of a FR-1, a growth factor-inducible aldo-keto reductase. Biochemistry 37, 12909-12917, 1998.
- Srivastava, S., Chandra, A., Wang, L., Seifert, W.E. Jr., Dague, B.B., Ansari, N.H., Srivasrava, S.K., and Bhatnagar, A. Metabolism of lipid peroxidation product, 4-hydroxy trans-2-nonenal in isolated rat heart. J. Biol. Chem. 273, 10893-10890, 1998.
